Recombinant Human AAK1 cell lysate

• Cat.No.: AAK1-2106HCL

Specification

• Description: Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: AAK1 AP2 associated kinase 1 [ Homo sapiens ]
• Official Symbol: AAK1
• Synonyms: AAK1; AP2 associated kinase 1; AP2-associated protein kinase 1; DKFZp686K16132; KIAA1048; adaptor-associated kinase 1; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; MGC138170; MGC164568; MGC164570; DKFZp686F03202
• Gene ID: 22848
• mRNA Refseq: NM_014911
• Protein Refseq: NP_055726
• UniProt ID: Q2M2I8
• Chromosome Location: 2p24.3-p14
• Function: AP-2 adaptor complex binding; ATP binding; Notch binding; nucleotide binding; protein serine/threonine kinase activity