Recombinant Human DAAM1 cell lysate

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Recombinant Human DAAM1 cell lysate

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Cat.No. : DAAM1-2111HCL
Description : Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
Species : Human
Size : 100 ug
Recommended Usage : Use it directly for immuno-precipitation, or heat lysate with SDS gel loading buffer to 95°C for 5 minutes followed by rapid cooling for western blot application. If dissociating conditions are required, add reducing agent prior to heating.
Storage Buffer : In modified RIPA Lysis Buffer.
Applications : Western Blot;Immunoprecipitation;
Gene Name : DAAM1 dishevelled associated activator of morphogenesis 1 [ Homo sapiens ]
Official Symbol : DAAM1
Synonyms : DAAM1; dishevelled associated activator of morphogenesis 1; disheveled-associated activator of morphogenesis 1; KIAA0666; FLJ41657;
Gene ID : 23002
mRNA Refseq : NM_014992
Protein Refseq : NP_055807
MIM : 606626
UniProt ID : Q9Y4D1
Chromosome Location : 14q22.3
Pathway : Noncanonical Wnt signaling pathway, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem;
Function : Rho GTPase binding; actin binding; binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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