Active Recombinant Human NEK11, GST-tagged

• Cat.No.: NEK11-1063H
• Product Overview: Recombinant full-length human NEK11 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 25 nmol/min/mg
• Molecular Mass: ~110 kDa
• Protein length: Full Length
• Purity: >90%
• Applications: Kinase Assay; Western Blot
• Stability: 1 yr at -70oC from date of shipment.
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: NEK11?NIMA-related kinase 11 [?Homo sapiens?(human) ]
• Official Symbol: NEK11
• Synonyms: NEK11; NIMA-related kinase 11; serine/threonine-protein kinase Nek11; NIMA (never in mitosis gene a)- related kinase 11; NP_001139475.1; EC 2.7.11.1; NP_079076.3; NP_665917.1
• Gene ID: 79858
• mRNA Refseq: NM_024800
• Protein Refseq: NP_079076
• MIM: 609779
• UniProt ID: Q8NG66
• Chromosome Location: 3q22.1
• Function: ATP binding; metal ion binding; protein serine/threonine kinase activity