Recombinant Human NFKBIB, GST-tagged

• Cat.No.: NFKBIB-4862H
• Product Overview: Recombinant full-length human IkBB was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Description: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~56 kDa
• Protein length: Full Length
• Purity: >90%
• Applications: Kinase Assay; Western Blot
• Stability: 1 yr at -70oC from date of shipment.
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 ug/ul

Gene Information

• Gene Name: NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [ Homo sapiens ]
• Official Symbol: NFKBIB
• Synonyms: NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; NF-kappa-B inhibitor beta; IKBB; TRIP9; ikB-B; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB; I-kappa-B-beta; TR-interacting protein 9; thyroid receptor-interacting protein 9
• Gene ID: 4793
• mRNA Refseq: NM_002503
• Protein Refseq: NP_002494
• MIM: 604495
• UniProt ID: Q15653
• Chromosome Location: 19q13.1
• Pathway: Activated TLR4 signalling; Adaptive Immune System; B cell receptor signaling pathway
• Function: protein binding; signal transducer activity; transcription coactivator activity