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Recombinant Human Myeloperoxidase

Cat.No.: MPO-63H
Product Overview: Recombinant Human Myeloperoxidase was expressed in E. coli.
Description: Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in polymorphonuclear leukocytes (neutrophils) and secreted during their activation. The presence of a peroxidase in the cytoplasmic granules of leukocytes was suggested at the beginning of 20th century but it was the early 1940s that it was purified for the first time.Native MPO is a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 – 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW about 150 kDa and theoretical pI 9.2. MPO plays an important role in neutrophil microbicidal action through catalyzing chloride ion oxidation to hypochlorous acid, which is a potent antimicrobial agent.
Source: E. coli
Species: Human
Form: The protein solution is in 0.05M phosphate buffer containing 0.15M NaCl and 0.09% NaN3 pH 7.5. Filtered through a 0.4μM membrane
Molecular Mass: 14.4kDa
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >95 % as determined by SDS-PAGE
Applications: Western blotting, ELISA
Storage: Store it under sterile conditions at -20℃ to -112℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.
Gene Name: MPO myeloperoxidase [ Homo sapiens ]
Official Symbol: MPO
Synonyms: MPO; myeloperoxidase;
Gene ID: 4353
mRNA Refseq: NM_000250
Protein Refseq: NP_000241
MIM: 606989
UniProt ID: P05164
Chromosome Location: 17q21.3-q23
Pathway: C-MYB transcription factor network, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Selenium Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem;
Function: chromatin binding; heme binding; heparin binding; metal ion binding; oxidoreductase activity; peroxidase activity;

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