Recombinant Human COL3A1

• Cat.No.: COL3A1-72H
• Product Overview: Recombinant Human Collagen, type III, alpha 1 was expressed in E. coli.

Specification

• Description: Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.By fluorescence in situ hybridization, Limongi et al. (1997) concluded that the COL3A1 gene is located in chromosome band 2q32.2 and that the nebulin gene is located in band 2q24.2; the FRA2G fragile site was found to lie between the 2 genes in the 2q31 band.
• Source: E. coli
• Species: Human
• Form: The protein solution is in 0.05M phosphate buffer containing 0.15M NaCl and 0.09% NaN3 pH 7.5. Filtered through a 0.4μM membrane.
• Molecular Mass: 68.9kDa
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Applications: Western blotting, ELISA
• Storage: Store it under sterile conditions at -20℃ to -122℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.

Gene Information

• Gene Name: COL3A1 collagen, type III, alpha 1 [ Homo sapiens ]
• Official Symbol: COL3A1
• Synonyms: COL3A1; collagen, type III, alpha 1; EDS4A, Ehlers Danlos syndrome type IV, autosomal dominant; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant; EDS4A; FLJ34534
• Gene ID: 1281
• mRNA Refseq: NM_000090
• Protein Refseq: NP_000081
• MIM: 120180
• UniProt ID: P02461
• Chromosome Location: 2q32.2
• Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Endothelins, organism-specific biosystem
• Function: SMAD binding; extracellular matrix structural constituent; integrin binding; integrin binding; platelet-derived growth factor binding; protein binding

Reviews

01/23/2020

This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

05/08/2019

The COL3A1 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

07/27/2016

the COL3A1 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

Q&As

How can the study of COL3A1 protein aid in the development of personalized medicine for vEDS patients?

Understanding the specific genetic and protein alterations in vEDS patients can help tailor individualized treatment strategies based on the patient's unique molecular profile.

Can COL3A1 protein analysis be used for prenatal screening of vEDS?

Yes, analysis of COL3A1 protein levels in prenatal samples may provide valuable information for assessing the risk of vEDS in the developing fetus.

How can the measurement of COL3A1 protein levels aid in the early detection of vEDS?

Elevated or decreased levels of COL3A1 protein may serve as potential biomarkers for early detection and risk assessment of vEDS, especially in at-risk individuals or families.

What are the current challenges in the clinical application of COL3A1 protein analysis?

Challenges include the need for standardized assays and reference ranges for COL3A1 protein levels, as well as the interpretation of results in the context of individual patient variability.

Can the measurement of COL3A1 protein levels be used to monitor disease progression in vEDS patients?

Yes, monitoring changes in COL3A1 protein levels may provide insights into disease progression and response to treatment in vEDS patients.