Active Native Apis mellifera Phospholipase A2

• Cat.No.: Pla2-85A
• Product Overview: Native Apis mellifera Phospholipase A2 was purified from honey bee venom.

Specification

• Description: Phospholipases A2 (PLA2s) EC 3.1.1.4 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators.
• Source: Honey bee venom
• Species: Honey bee
• Form: salt-free, lyophilized powder
• Bio-activity: 600-2400 units/mg protein
• Unit Definition: One unit will hydrolyze 1.0 μmole of soybean L-α-phosphatidylcholine to L-α-lysophosphatidylcholine and a fatty acid per min at pH 8.9 at 25 °C.
• Storage: Store at -20 °C

Gene Information

• Gene Name: Pla2 phospholipase A2 [ Apis mellifera ]
• Official Symbol: Pla2
• Synonyms: bvPLA2; GB13351; phospholipase A2; allergen Api m 1; allergen Api m Iphosphatidyl; choline 2-acylhydrolase
• Gene ID: 406141
• mRNA Refseq: NM_001011614
• Protein Refseq: NP_001011614
• UniProt ID: P00630
• Chromosome Location: chromosome: LG13