Recombinant Cynomolgus CD274, Fc-tagged

Cat.No.: CD274-167C
Product Overview: Recombinant Cynomolgus PDL1 /CD274 Protein, C-Fc Tag (Cynomolgus PDL1 /CD274 Fc Chimera) Phe 19 - Arg 238 (Accession # F6VEW6) was produced in human 293 cells (HEK293).
Description: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Source: HEK293
Species: Cynomolgus
Tag: Fc
Predicted N Terminal: Phe 19
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Cynomolgus PDL1 /CD274 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 51.8 kDa. The predicted N-terminus is Phe 19. DTT-reduced Protein migrates as 66-80 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Cynomolgus PDL1 /CD274 Fc Chimera by the LAL method.
Purity: >90% as determined by SDS-PAGE.
Applications: CD Antigens
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: CD274?CD274 molecule [?Macaca fascicularis?(crab-eating macaque) ]
Official Symbol: CD274
Synonyms: CD274; CD274 molecule; hypothetical protein; programmed cell death ligand 1
Gene ID: 102145573
mRNA Refseq: XM_005581780
Protein Refseq: XP_005581837
Chromosome Location: 15
Pathway: Cell adhesion molecules (CAMs)

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