Recombinant Mouse Cpe, His-tagged, C13&N15 Labeled

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Recombinant Mouse Cpe, His-tagged, C13&N15 Labeled

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Cat.No. : Cpe-203M
Product Overview : Recombinant Mouse CPE MS Standard Protein, C13 and N15-labeled (Mouse CPE, Heavy Labeled) Gln 28 - Phe 476 (Accession # NP_038522) was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain >99% incorporation effi
Description : Carboxypeptidase E (CPE) is also known as Carboxypeptidase H or enkephalin convertase. Carboxypeptidase E cleaves C-terminal amino acid residues and is involved in neuropeptide processing. It is a peripheral membrane protein. CPE specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Carboxypeptidase E appears to have several functions. The active form of carboxypeptidase E was shown to be in secretory vesicles, where it acts as an exopeptidase to activate neuropeptides, It does that by cleaving off basic C-terminal amino acids, producing the active form of the peptide. Products of carboxypeptidase E include insulin, enkephalin, and most other neuroendocrine peptides.It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting signal for regulated secretory proteins in the trans-Golgi network of the pituitary and in secretory granules; regulated secretory proteins are mostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe, display endocrine disorders like obesity and infertility.
Source : HEK293
Species : Mouse
Tag : His
Predicted N Terminal : Gln 28
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass : Mouse CPE, Heavy Labeled is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 52 kDa. The predicted N-terminus is Gln 28. DTT-reduced Protein migrates as 52 kDa in SDS-PAGE.Mouse CPE, Heavy Labeled is labeled with [U- 13C6, 15N4]
Endotoxin : Less than 1.0 EU per μg of the Mouse CPE, Heavy Labeled by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Applications : MS Standard Protein
Storage : Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name : Cpe carboxypeptidase E [ Mus musculus ]
Official Symbol : Cpe
Synonyms : CPE; carboxypeptidase E; carboxypeptidase H; enkephalin convertase; prohormone-processing carboxypeptidase; CPH; fat; Cph1; Cph-1; R74677; MGC7101;
Gene ID : 12876
mRNA Refseq : NM_013494
Protein Refseq : NP_038522
Pathway : Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem; Type I diabetes mellitus, organism-specific biosystem; Type I diabetes mellitus, conserved biosystem;
Function : carboxypeptidase activity; cell adhesion molecule binding; cobalt ion binding; hydrolase activity; metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; neurexin family protein binding; peptidase activity; zinc ion binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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