Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ATAD2, His&FLAG-tagged

Cat.No. : ASH1L-30H
Product Overview : Recombinant Human ASH1L corresponding to amino acids 2407-2579 that contains the bromodomain sequences of ASH1L (accession number NP_060959.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag.
  • Specification
  • Gene Information
  • Related Products
Description : ASH1L is a member of the Trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. The bromodomain functions as a "reader" of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. ASH1L is localized to the nucleus and also to cell-cell tight junctions where it is hypothesized to function in adhesion-mediated signaling. ASH1L functions in methylation of H3K4 and regulation of expression of HOX genes and may possess methyltransferase activity directed at H3K36. ASH1L has also been implicated in facioscapulohumeral muscular dystrophy.
Source : E. coli
Species : Human
Tag : His&FLAG
Form : 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol.
Molecular Mass : 25.6 kDa
Applications : Binding assays, inhibitor screening, and selectivity profiling.
Storage : Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Concentration : 6.7 mg/ml
Gene Name : ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) [ Homo sapiens ]
Official Symbol : ASH1L
Synonyms : ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila); histone-lysine N-methyltransferase ASH1L; ASH1; ASH1L1; huASH1; KMT2H; ASH1-like protein; lysine N-methyltransferase 2H; absent small and homeotic disks protein 1 homolog; probable histone-lysine N-methyltransferase ASH1L; FLJ10504; KIAA1420;
Gene ID : 55870
mRNA Refseq : NM_018489
Protein Refseq : NP_060959
MIM : 607999
UniProt ID : Q9NR48
Chromosome Location : 1q22
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem;
Function : DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All ASH1L Products

Required fields are marked with *

My Review for All ASH1L Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends