Active Recombinant Human KDM3B, FLAG-tagged

• Cat.No.: KDM3B-49H
• Product Overview: Recombinant Human KDM3B (accession number NP_057688.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with a molecular weight of 193.4 kDa.

Specification

• Description: Lysine (K)-specific demethylase 3B (KDM3B), also known as Jumonji domain-containing protein 1B (JMJD1B), is a histone demethylase that specifically demethylates lysine 9 of histone H3 (H3K9), thereby playing a central role in defining the histone code. Demethylation of lysine residues generates formaldehyde and succinate. KDM3B may have tumor suppressor activity.
• Source: Sf9 insect cells
• Species: Human
• Tag: FLAG
• Form: 40 mM HEPES pH 7.4, 150 mM NaCl and 20% glycerol.
• Bio-activity: H3K9me2 demethylase.
• Applications: Enzyme kinetics, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.9 mg/ml

Gene Information

• Gene Name: KDM3B lysine (K)-specific demethylase 3B [ Homo sapiens ]
• Official Symbol: KDM3B
• Synonyms: KDM3B; lysine (K)-specific demethylase 3B; C5orf7, chromosome 5 open reading frame 7 , JMJD1B, jumonji domain containing 1B; lysine-specific demethylase 3B; KIAA1082; NET22; nuclear protein 5qNCA; jumonji domain containing 1B; jumonji domain-containing protein 1B; jmjC domain-containing histone demethylation protein 2B; 5qNCA; C5orf7; JMJD1B
• Gene ID: 51780
• mRNA Refseq: NM_016604
• Protein Refseq: NP_057688
• MIM: 609373
• UniProt ID: Q7LBC6
• Chromosome Location: 5q31
• Function: metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen