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Active Recombinant Mouse Lbp, His-tagged

Cat.No. : Lbp-248M
Product Overview : Recombinant Mouse Lbp, Gly25-Val481 (Ser102Arg, Tyr284His), fused with a C-terminal 6-His tag, was expressed in Mouse NSO Cells.
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Description : Lipopolysaccharide binding protein is a proteinthat in humans is encoded by the LBP gene.
Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : Gly25
Form : Lyophilized from a 0.2 µm filtered solution in MES, NaCl, PEG and CHAPS.
Bio-activity : Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP-1 human acute monocytic leukemia cells.
Molecular Mass : Predicted Molecular Mass: 51.5 kDaSDS-PAGE: 60-65 kDa, reducing conditions
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 µg/mL in PBS.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : Lbp lipopolysaccharide binding protein [ Mus musculus (house mouse) ]
Official Symbol : Lbp
Synonyms : Lbp; lipopolysaccharide binding protein; Ly88; Bpifd2
Gene ID : 16803
mRNA Refseq : NM_008489
Protein Refseq : NP_032515
UniProt ID : Q61805
Chromosome Location : 2 H1; 2 78.72 cM
Pathway : Innate Immune System; NF-kappa B signaling pathway; Transfer of LPS from LBP carrier to CD14
Function : lipid binding; lipopolysaccharide binding; receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What happens if LPS cannot make close contact with TLR4? 10/17/2022

If LPS's chemical spatial configuration prevents close contact with TLR4, it exhibits an antagonistic effect, inhibiting the cellular response.

What is the role of Toll-like receptor 4 (TLR4) in this process? 04/21/2022

LPS on the LBP-LPS complex, upon close physical contact with TLR4 on cells, induces TLR4 receptor dimerization or multimerization. This activates various transcription factors, leading to the expression of inflammatory mediators and cytokines.

How does the LBP-LPS complex interact with cells lacking mCD14 receptors? 03/21/2021

For cells without membrane CD14 receptors (e.g., endothelial and epithelial cells), a soluble CD14 (sCD14)-LBP-LPS ternary complex forms, activating TLR4 and inducing various biological effects.

What does LBP stand for? 09/17/2018

LBP stands for Lipopolysaccharide-Binding Protein.

What is the main function of LBP? 02/09/2018

LBP has a high affinity for the lipid A portion in the structure of Lipopolysaccharide (LPS) and forms the LPS-LBP complex.

What is the significance of the LPS-LBP complexes in liver cells? 12/02/2016

Liver cells, similar to macrophages, express mCD14 and TLR4. In the absence of CD14 receptors, LPS can still bind to TLR4, but with relatively weaker intensity.

How does the LBP-LPS complex interact with cells? 08/04/2016

The LBP-LPS complex can transfer LPS to membrane CD14 (mCD14) receptors on cells like monocytes, macrophages, and neutrophils.

Customer Reviews (3)

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Reviews
12/15/2022

    We appreciated the product's efforts to minimize its environmental footprint through sustainable manufacturing practices.

    10/24/2021

      Its adaptability to various sample types and conditions made it a valuable asset for our diverse projects.

      10/27/2018

        The product's versatility allowed us to apply it to a wide range of experimental techniques and research areas.

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