Recombinant Human FOXA2

• Cat.No.: FOXA2-127H
• Product Overview: Recombinant full-length human FOXA2 was expressed in E. coli and refolded to soluble form.

Specification

• Description: FOXA2 is a member of the forkhead box family of DNA-binding proteins. FOXA2 is a hepatocyte nuclear factor (specifically, HNF-3β) that is a transcriptional activator for liver-specific genes such as albumin. During embryonic development, FOXA2 expression is a marker for cells of the definitive (but not primitive) endoderm lineage.
• Source: E. coli
• Species: Human
• Form: 244 µg/ml (determined by Bradford assay) in 500 mM L-arginine, 300 mM guanidine-HCl, 50 mM HEPES, 5 mM cystamine, 5 mM cysteamine, 5 mM CaCl2, 3 mM DTT, pH 7.5.
• Molecular Mass: 457 residues; 48.3 kDa
• Purity: >90% by SDS-PAGE
• Storage: Store at -80 °C. Avoid multiple freeze-thaws.

Gene Information

• Gene Name: FOXA2 forkhead box A2 [ Homo sapiens ]
• Official Symbol: FOXA2
• Synonyms: FOXA2; forkhead box A2; hepatocyte nuclear factor 3, beta , HNF3B; hepatocyte nuclear factor 3-beta; HNF-3B; TCF-3B; HNF-3-beta; forkhead box protein A2; transcription factor 3B; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; HNF3B; TCF3B; MGC19807
• Gene ID: 3170
• mRNA Refseq: NM_021784
• Protein Refseq: NP_068556
• MIM: 600288
• UniProt ID: Q9Y261
• Chromosome Location: 20p11
• Pathway: Developmental Biology, organism-specific biosystem; FOXA transcription factor networks, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Heart Development, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem
• Function: DNA binding; DNA binding, bending; RNA polymerase II core promoter proximal region sequence-specific DNA binding; SMAD binding; double-stranded DNA binding; protein domain specific binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription factor binding; transcription regulatory region DNA binding