Recombinant Human Retinoic acid receptor alpha, GST-tagged

• Cat.No.: RARA-111H
• Product Overview: Recombinant Human GST-tagged Retinoic acid receptor alpha ligand-binding domain (RARA-LBD) consists of a 218 a.a. GST tag, a 14 a.a. flexible linker and a 288 a.a. RARA-LBD, Acc# AAH71733.1, amino acids 170-457. GST tagged RARA-LBD was expressed in baculovirus-infected insect cells and purified using affinity chromatography.

Specification

• Description: Retinoic acid receptor alpha (RAR-alpha or RARA) is also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1).
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 0.5 mM EDTA, 3 mM Dithiothreitol, 7 mM reduced glutathione, 20% glycerol.
• Purity: >90%
• Applications: Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.

Gene Information

• Gene Name: RARA retinoic acid receptor, alpha [ Homo sapiens ]
• Official Symbol: RARA
• Synonyms: RARA; retinoic acid receptor, alpha; retinoic acid receptor alpha; NR1B1; RAR; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
• Gene ID: 5914
• mRNA Refseq: NM_000964
• Protein Refseq: NP_000955
• MIM: 180240
• UniProt ID: P10276
• Chromosome Location: 17q21.1
• Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipogenesis, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem
• Function: chromatin DNA binding; enzyme binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor activity; receptor binding; retinoic acid binding; retinoic acid receptor activity; retinoic acid-responsive element binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription coactivator activity; transcription coactivator activity; transcription corepressor activity; transcription factor binding; zinc ion binding