Native Human AMBP
Cat.No. : | AMBP-27H |
Product Overview : | Alpha 1-microglobulin (A1M) is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function. Purified from the urine of patients with chronic renal tubular proteinuria. |
- Specification
- Gene Information
- Related Products
Species : | Human |
Form : | Lyophilized from 0.02M NH4HCO3. |
Purity : | Greater than 96.0%. |
Applications : | Inhibition of stimulation of cultured lymphocytes by protein antigens; induction of cell division of lymphocytes, a mitogenic effect that can either be enhanced or inhibited by the action of other plasma components; inhibition of neutrophil granulocyte migration in vitro; and inhibition of chemotaxis. |
Usage : | This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use. |
Storage : | Human A1M although stable at room temperature for 3 weeks, should be stored between 2-8°C. |
Reconstitution : | Use phosphate buffer, pH>7.0 containing 0.15M NaCl, is recommended. |
Gene Name : | AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens ] |
Official Symbol : | AMBP |
Synonyms : | AMBP; alpha-1-microglobulin/bikunin precursor; ITI, ITIL; protein AMBP; bikunin; complex forming glycoprotein heterogeneous in charge; EDC1; growth inhibiting protein 19; HCP; HI30; IATIL; inter alpha trypsin inhibitor light chain; ITILC; protein HC; tryp |
Gene ID : | 259 |
mRNA Refseq : | NM_001633 |
Protein Refseq : | NP_001624 |
MIM : | 176870 |
UniProt ID : | P02760 |
Chromosome Location : | 9q32-q33 |
Function : | IgA binding; calcium channel inhibitor activity; calcium oxalate binding; heme binding; peptidase inhibitor activity; protein homodimerization activity; serine-type endopeptidase inhibitor activity; transporter activity; |
Products Types
◆ Recombinant Protein | ||
AMBP-127H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
AMBP-302R | Recombinant Rat AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-331H | Recombinant Human AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
Ambp-590M | Recombinant Mouse Ambp Protein, MYC/DDK-tagged | +Inquiry |
AMBP-128H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
AMBP-5312H | Native Human Alpha-1-Microglobulin/Bikunin Precursor | +Inquiry |
◆ Lysates | ||
AMBP-001HCL | Recombinant Human AMBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.
AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.
AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.
AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.
Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.
AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.
AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.
AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.
AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.
The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.
Customer Reviews (3)
Write a reviewCompatibility with various protein modification detection methods.
Enhanced data reproducibility in protein quantification.
Comprehensive profiling of protein expression patterns.
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