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Native Human Activated Protein C

Cat.No.: PROC-64H
Description: The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on SDS-PAGE. Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.
Source: Human Plasma
Species: Human
Form: Liquid
Bio-activity: Lot dependent
Molecular Mass: 56 kDa
Purity: Purity by SDS-PAGE: ≥95%
Usage: For Research Use Only! Not For Use in Humans.
Notes: Centrifuge the vial prior to opening
Storage Buffer: In 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4
Shipping: Dry Ice
Gene Name: PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ]
Official Symbol: PROC
Synonyms: PROC; protein C (inactivator of coagulation factors Va and VIIIa); vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV; PC; APC; PROC1; THPH3; THPH4;
Gene ID: 5624
mRNA Refseq: NM_000312
Protein Refseq: NP_000303
MIM: 612283
UniProt ID: P04070
Chromosome Location: 2q13-q14
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem;
Function: calcium ion binding; peptidase activity; protein binding; serine-type endopeptidase activity;

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