Native Human lactoferrin

• Cat.No.: LTF-175H

Specification

• Description: Lactoferrin is a glycoprotein present in most human mucosal secretions, including human milk. Lactoferrin is bacteriostatic in low iron media and, in some settings, bactericidal. Lactoferrin impairs ability of Shigella flexneri serotype 5 strain M90T to invade HeLa cells. To determine the mechanism by which lactoferrin decreases invasiveness of Shigella organisms, its effect on the major virulence proteins responsible for bacterial uptake by host cells was evaluated. Lactoferrin induced degradation of invasion plasmid antigens IpaB and, to a lesser extent, IpaC, the key proteins responsible for bacteria-directed phagocytosis by mammalian cells.
• Source: Purified from human milk
• Species: Human
• Form: Liquid
• Protein length: Full length native Human lactoferrin
• Purity: >95% (SDS-PAGE)
• Applications: Western blotting,ELISA,etc.
• Storage: Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage Buffer: Tris pH8.0

Gene Information

• Gene Name: LTF lactotransferrin [ Homo sapiens ]
• Official Symbol: LTF
• Synonyms: LTF; lactotransferrin; HLF2; talalactoferrin; neutrophil lactoferrin; growth-inhibiting protein 12; LF; GIG12
• Gene ID: 4057
• mRNA Refseq: NM_001199149
• Protein Refseq: NP_001186078
• MIM: 150210
• UniProt ID: P02788
• Chromosome Location: 3p21.31
• Pathway: Amyloids, organism-specific biosystem; Disease, organism-specific biosystem
• Function: ferric iron binding; heparin binding; metal ion binding; peptidase activity; protein binding; serine-type endopeptidase activity