Native Bovine α-Thrombin-BFPRck (Biotin)


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Native Bovine α-Thrombin-BFPRck (Biotin)

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Cat.No. : F2-277B
Description : Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII. Thrombin has also been reported to activate factor XIII and platelets, and also functions as a vasoconstrictor protein. The procoagulant activity of thrombin is arrested in two ways: 1) inhibition by either heparin cofactor II or the antithrombin III/heparin complex; or 2) complex formation with thrombomodulin. Formation of the thrombin/thrombomodulin complex results in the inability of thrombin to cleave fibrinogen and activate factors V and VIII, but increases the efficiency of thrombin for activation of the anticoagulant, protein C.
Source : Plasma
Species : Bovine
Form : 20 mM Hepes, 150 mM NaCl, pH 7.4
Bio-activity : Fibrinogen clotting or chromogenic assay
Molecular Mass : 36700
Purity : >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin.
Characteristic : Extinction coefficient:19.5, Percent carbohydrate: approximately 5%, Structure: two subunits, approximately Mr=6,000 and 31,000
Storage : -80°C
Gene Name : F2?coagulation factor II (thrombin) [?Bos taurus?(cattle) ]
Official Symbol : F2
Synonyms : prothrombin; thrombin
Gene ID : 280685
mRNA Refseq : NM_173877
Protein Refseq : NP_776302
UniProt ID : P00735
Chromosome Location : chromosome: 15
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem
Function : calcium ion binding; fibrinogen binding

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