Recombinant Human USP20, GST-tagged


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Recombinant Human USP20, GST-tagged

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Cat.No. : USP20-162H
Product Overview : Recombinant human USP20 (amino acid residues 1-913), fused with N-terminal GST, was expressed in Insect sf21.
Description : There are two main classes of DUB, cysteine proteases and metalloproteases. Ubiquitin specific protease 20 (USP20) is a member of the cysteine protease enzyme family and cloning of the gene was first described by Nagase et al. (1999). USP20 has been shown to specifically deubiquitylate and stabilise Hypoxia-inducible factor (HIF)-1α, increasing expression of HIF-1α targeted genes, such as vascular endothelial growth factor (VEGF) (Li et al., 2005). USP20 also deubiquitylates tumour necrosis receptor-associated factor 6 (TRAF6) and Tax and suppresses interleukin 1β (IL-1β) and Tax-induced NF-κB activation.
Source : Insect cells
Species : Human
Tag : GST
Form : 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
Bio-activity : Deubiquitylase Enzyme Assay: The activity of GST-USP20 was validated by determining the increase in fluorescence measured as a result of the enzyme catalysed cleavage of the fluorogenic substrate Ubiquitin-Rhodamine110-Glycine generating Ubiquitin and Rhodamine110-Glycine. Incubation of the substrate in the presence or absence of GST-USP20 was compared confirming the deubiquitylating activity of GST-USP20.
Molecular Mass : 128.7 kDa
Purity : >70% by SDS-PAGE
Storage : 12 months at -70°C. Avoid multiple freeze/thaw cycles.
Concentration : 0.5 mg/ml
Gene Name : USP20 ubiquitin specific peptidase 20 [ Homo sapiens ]
Official Symbol : USP20
Synonyms : USP20; ubiquitin specific peptidase 20; ubiquitin specific protease 20; ubiquitin carboxyl-terminal hydrolase 20; KIAA1003; hVDU2; ubiquitin thioesterase 20; deubiquitinating enzyme 20; ubiquitin thiolesterase 20; VHL-interacting deubiquitinating enzyme 2; ubiquitin-specific-processing protease 20; pVHL-interacting deubiquitinating enzyme 2; VDU2; LSFR3A;
Gene ID : 10868
mRNA Refseq : NM_001008563
Protein Refseq : NP_001008563
UniProt ID : Q9Y2K6
Chromosome Location : 9q34.2
Function : G-protein coupled receptor binding; cysteine-type endopeptidase activity; metal ion binding; peptidase activity; ubiquitin thiolesterase activity; zinc ion binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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