Recombinant Canine SERPINE1 SERPINE1-90C

Recombinant Canine SERPINE1

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Recombinant Canine SERPINE1

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Cat.No. : SERPINE1-90C
Product Overview : Glycosylated wild type dog PAI-1 produced in insect cells. Latent form.
Description : PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
Source : Insect cell culture
Species : Canine
Form : Frozen liquid
Bio-activity : >95% active by uPA titration and SDS-PAGE
Molecular Mass : 46000
Purity : >95% by SDS-PAGE analysis
Storage : Store at -70°C. Avoid repeated freeze-thaw cycles.
Concentration : 1.0 mg/ml
Storage Buffer : 0.05M Sodium Acetate; 0.1M NaCl; 1mM EDTA; pH 5.0
Gene Name : SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [ Canis lupus familiaris (dog) ]
Official Symbol : SERPINE1
Synonyms : SERPINE1; PAI-1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inhibitor 1; plasminogen activator inhibitor type 1
Gene ID : 403476
mRNA Refseq : NM_001197095
Protein Refseq : NP_001184024
Chromosome Location : 6
Pathway : BMAL1:CLOCK,NPAS2 activates circadian gene expression; Chagas disease (American trypanosomiasis); HIF-1 signaling pathway

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