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Active Recombinant Human TET1, Flag-tagged

Cat.No. : TET1-997H
Product Overview : Recombinant Human TET1(1418 a.a. - 2136 a.a.), fused with FLAG-tag at N-terminal, was expressed in Baculovirus infected sf9 cell expression system.
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Description : Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes that in humans is encoded by the TET1 gene. TET1 catalyzes the conversion of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). TET1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate dependent manner. The conversion of 5-mC to 5-hmC has been proposed as the initial step of active DNA demethylation in mammals.
Source : sf9 Cells
Species : Human
Tag : Flag
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol in the elution buffer.
Molecular Mass : 80 kDa
Purity : >80% purity
Applications : Active DNA demethylase can be used for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing. Best when used within six months from the date of receipt.
Gene Name : TET1 tet methylcytosine dioxygenase 1 [ Homo sapiens (human) ]
Official Symbol : TET1
Synonyms : TET1; tet methylcytosine dioxygenase 1; LCX; CXXC6; bA119F7.1; methylcytosine dioxygenase TET1; CXXC finger 6; tet oncogene 1; CXXC zinc finger 6; TET1 splice variant VP_DE4; ten-eleven translocation-1; TET1 splice variant VP_DE456; CXXC-type zinc finger protein 6; ten-eleven translocation 1 gene protein; leukemia-associated protein with a CXXC domain; NP_085128.2; EC 1.14.11.n2
Gene ID : 80312
mRNA Refseq : NM_030625
Protein Refseq : NP_085128
MIM : 607790
UniProt ID : Q8NFU7
Chromosome Location : 10q21
Pathway : Epigenetic regulation of gene expression; Gene Expression; TET1,2,3 and TDG demethylate DNA
Function : iron ion binding; methylcytosine dioxygenase activity; structure-specific DNA binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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