"TNFRSF18" Related Products

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Recombinant Human TNFRSF18

Cat.No.: TNFRSF18-925H
Product Overview: Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL.
Description: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Source: E. coli
Species: Human
Form: lyophilized
Bio-activity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors.
Molecular Mass: 14.3 kDa
AA Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI
Endotoxin: < 0.1 ng per µg of AITRL
Purity: >97% by SDS-PAGE gel and HPLC analyses.
Usage: Human AITRL offered for research use. Not for drug use. Not for human use.
Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted Human AITRL should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Reconstitution: The human AITRL should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Gene Name: TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens (human) ]
Official Symbol: TNFRSF18
Synonyms: Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand
Gene ID: 8995
mRNA Refseq: NM_005092
Protein Refseq: NP_005083
MIM: 603898
UniProt ID: Q9UNG2
Chromosome Location: 1q23
Pathway: Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells
Function: tumor necrosis factor-activated receptor activity

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