Active Recombinant Human TNFRSF18

• Cat.No.: TNFRSF18-925H
• Product Overview: Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL.

Specification

• Description: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Source: E. coli
• Species: Human
• Form: lyophilized
• Bio-activity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors.
• Molecular Mass: 14.3 kDa
• AA Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI
• Endotoxin: < 0.1 ng per µg of AITRL
• Purity: >97% by SDS-PAGE gel and HPLC analyses.
• Usage: Human AITRL offered for research use. Not for drug use. Not for human use.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted Human AITRL should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
• Reconstitution: The human AITRL should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.

Gene Information

• Gene Name: TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF18
• Synonyms: Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand
• Gene ID: 8995
• mRNA Refseq: NM_005092
• Protein Refseq: NP_005083
• MIM: 603898
• UniProt ID: Q9UNG2
• Chromosome Location: 1q23
• Pathway: Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells
• Function: tumor necrosis factor-activated receptor activity