"BID" Related Products

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Recombinant Human BH3 Interacting Domain Death Agonist

Cat. No.: BID-380H
Product Overview: Recombinant BID protein was expressed in E.coli and purified by using conventional chromatography techniques, 21.9 kDa (195 aa).
Description: BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases.
Sequences of amino acids: MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Purity: > 95% by SDS - PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: BID BH3 interacting domain death agonist [ Homo sapiens ]
Synonyms: BID; BH3 interacting domain death agonist; FP497; MGC15319; MGC42355; BID isoform Si6; BID isoform L(2); BID isoform ES(1b);OTTHUMP00000196197; desmocollin type 4; apoptic death agonist; Human BID coding sequence; BH3-interacting domain death agonist; p22 BID
Gene ID: 637
mRNA Refseq: NM_001196
Protein Refseq: NP_001187
MIM: 601997
UniProt ID: P55957
Chromosome Location: 22q11.1
Pathway: Apoptosis; Natural killer cell mediated cytotoxicity; Apoptosis
Function: death receptor binding; protein binding

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