Recombinant Human Carbonyl Reductase 1

• Cat.No.: CBR1-142H
• Product Overview: Recombinant human CBR1 protein was expressed in E.coli and purified by using conventional chromatography, 30 kDa (277aa).

Specification

• Cat. No.: CBR1-142H
• Description: CBR1(Carbonyl reductase 1) is one of several monomericNADPH-dependentoxidoreductaseshaving wide specificity for carbonyl compounds. CBR1 is widely distributed in human tissues. CBR1 metabolizes many toxic environmentalquinonesand pharmacological relevant substrates such as the anticancerdoxorubicin. CBR1 can also convert prostaglandin E2 to prostaglandin F2-alpha.
• Sequences of amino acids: MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW
• Purity: > 95% by SDS - PAGE
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.5) containing 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Publication:
  Environmentally Robust Rhodamine Reporters for Probe-based Cellular Detection of the Cancer-linked Oxidoreductase hNQO1 (2015)

Gene Information

• Gene Name: CBR1 carbonyl reductase 1 [ Homo sapiens ]
• Synonyms: CBR1; CBR; hCBR1; SDR21C1; CBR1; CRN; carbonyl reductase (NADPH) 1, EC 1.1.1.184; carbonyl reductase 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; short chain dehydrogenase/reductase family 21C, member 1; EC 1.1.1.184; EC 1.1.1.189; EC 1.1.1.197; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase [NADP+].
• Gene ID: 873
• mRNA Refseq: NM_001757
• Protein Refseq: NP_001748
• MIM: 114830
• UniProt ID: P16152
• Chromosome Location: 21q22.13
• Pathway: Arachidonic acid metabolism
• Function: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; oxidoreductase activity; prostaglandin-E2 9-reductase activity; protein binding