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Recombinant Human Catechol-O-methyltransferase, His-tagged

Cat.No. : COMT-126H
Product Overview : Recombinant human COMT protein was expressed in E.coli and purified by using conventional chromatography techniques, 24.4 kDa (221 aa).
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Cat. No. : COMT-126H
Description : Catechol-O-methyltrasferase (COMT) is an enzyme that catalyses the transfer of the methyl group of S-adenosylmethionine (SAM) into catechol substrates such as levodopa, dopamine, epinephrine, and norepinephirine in the presence of Mg2+. COMT appears to be located in the postsynaptic neuron and plays roles in the metabolism of catechol estrogens and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson"s disease.
Sequences of amino acids : MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM MgCl210% glycerol
Purity : > 95% by SDS - PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Endotoxin Level : < 1.0 EU per 1ug of protein (determined by LAL method)
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : COMT catechol-O-methyltransferase [ Homo sapiens ]
Synonyms : catechol-O-methyltransferase; EC 2.1.1.6
Gene ID : 1312
mRNA Refseq : NM_000754
Protein Refseq : NP_000745
MIM : 116790
UniProt ID : P21964
Chromosome Location : 22q11.21-q11.23; 22q11.21
Pathway : Tyrosine metabolism; Biological oxidations; Synaptic Transmission
Function : catechol O-methyltransferase activity; catechol O-methyltransferase activity; magnesium ion binding; protein binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/06/2021

    Its purity, stability, and functionality make it an ideal choice for my research endeavors.

    09/16/2019

      The COMT protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

      04/09/2016

        Manufacturers should ensure the consistency and quality of COMT protein products.

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