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Recombinant Human Catechol-O-methyltransferase, His-tagged

Cat. No.: COMT-126H
Product Overview: Recombinant human COMT protein was expressed in E.coli and purified by using conventional chromatography techniques, 24.4 kDa (221 aa).
Description: Catechol-O-methyltrasferase (COMT) is an enzyme that catalyses the transfer of the methyl group of S-adenosylmethionine (SAM) into catechol substrates such as levodopa, dopamine, epinephrine, and norepinephirine in the presence of Mg2+. COMT appears to be located in the postsynaptic neuron and plays roles in the metabolism of catechol estrogens and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson"s disease.
Sequences of amino acids: MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM MgCl210% glycerol
Purity: > 95% by SDS - PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Endotoxin Level: < 1.0 EU per 1ug of protein (determined by LAL method)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: COMT catechol-O-methyltransferase [ Homo sapiens ]
Synonyms: catechol-O-methyltransferase; EC 2.1.1.6
Gene ID: 1312
mRNA Refseq: NM_000754
Protein Refseq: NP_000745
MIM: 116790
UniProt ID: P21964
Chromosome Location: 22q11.21-q11.23; 22q11.21
Pathway: Tyrosine metabolism; Biological oxidations; Synaptic Transmission
Function: catechol O-methyltransferase activity; catechol O-methyltransferase activity; magnesium ion binding; protein binding; transferase activity

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