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Recombinant Human ERBB4, His-tagged

Cat.No.: ERBB4-7284H
Product Overview: Recombinant Human ErbB4 / HER4 Protein (rhErbB4) (Glu26-Pro 651) was produced in human 293 cells (HEK293).
Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Source: HEK293
Species: Human
Tag: His
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: Measured by its ability to inhibit the biological activity of Neuregulin-1-β1 on MCF-7 human breast cancer cells. In the presence of 10 ng/mL of Recombinant Human NRG1-β1/HRG1-β1 Extracellular Domain. The ED50 for this effect is typically 0.2-2.5 μg/mL.
Molecular Mass: rhErbB4, fused with 6×his tag at the C-terminus and has a calculated MW of 70.6 kDa expressed. The predicted N-terminal is Glu26. Protein migrates as 95-110 kDa in reduced SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rhErbB4 by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at: In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4o°C-8°C) or 3 months (-20°C to -70°C).
Reconstitution: See Certificate of Analysis for details of reconstitution instruction and specific concentration.
Gene Name: ERBB4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 [ Homo sapiens (human) ]
Official Symbol: ERBB4
Synonyms: ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4; Receptor tyrosine-protein kinase erbB-4; HER4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; EC 2.7.10.1; MGC138404; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4
Gene ID: 2066
mRNA Refseq: NM_005235
Protein Refseq: NP_005226
MIM: 600543
UniProt ID: Q15303
Chromosome Location: 2q33.3-q34
Pathway: Calcium signaling pathway; Endocytosis; ErbB signaling pathway
Function: ATP binding; nucleotide binding; protein binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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