"ABL2" Related Products

Recombinant Human ABL2, His-tagged

Cat.No.: ABL2-233H
Product Overview: Recombinant human ABL2 (38-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Description: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Source: Sf9 insect cells
Species: Human
Tag: His
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Bio-activity: 1218 nmol/min/mg
Molecular Mass: ~132 kDa
AA Sequence: 38-end
Purity: >70%
Applications: Kinase Assay, Western Blot
Stability: 1 yr at -70°C from date of shipment.
Storage: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/ul
Gene Name: ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Homo sapiens (human) ]
Official Symbol: ABL2
Synonyms: ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; Abelson murine leukemia viral (v-abl) oncogene homolog 2; OTTHUMP00000033140; OTTHUMP00000218106; abelson murine leukemia viral oncogene homolog 2; abelson-related gene protein; arg tyrosine kinase; tyrosine-protein kinase ABL2; tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); ARG; ABLL; FLJ22224; FLJ31718; FLJ41441; ABL2; EC 2.7.10.2
Gene ID: 27
mRNA Refseq: NM_005158
Protein Refseq: NP_005149
MIM: 164690
UniProt ID: P42684
Chromosome Location: 1q25.2
Pathway: Developmental Biology; ErbB signaling pathway; Role of Abl in Robo-Slit signaling
Function: ATP binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding

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