"DTNBP1" Related Products

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Recombinant Human Dystrobrevin Binding Protein 1

Cat. No. : DTNBP1-308H
Product Overview : Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography technique (307 aa, 34.6 kDa).
Description : Dysbindin is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes.
Source : E.coli.
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 0.5 mM DTT, 20% glycerol.
Molecular Weight : 34.6 kDa (307aa).
Purity : > 95% by SDS – PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequence : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMLS AHWEKKKTSL VELQEQLQQL PALIADLESM TANLTHLEAS FEEVENNLLH LEDLCGQCEL ERCKHMQSQQ LENYKKNKRK ELETFKAELD AEHAQKVLEM EHTQQMKLKE RQKFFEEAFQ QDMEQYLSTG YLQIAERREP IGSMSSMEVN VDMLEQMDLM DISDQEALDV FLNSGGEENT VLSPALGPES STCQNEITLQ VPNPSELRAK PPSSSSTCTD SATRDISEGG ESPVVQSDEE EVQVDTALAT SHTDREATPD GGEDSDS
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : DTNBP1
Synonyms : DTNBP1; dystrobrevin binding protein 1; SDY; DBND; HPS7; My031; FLJ30031; MGC20210; DKFZp564K192; C20orf35; CK1BP; HSMNP1; OTTHUMP00000031115; OTTHUMP00000031116; OTTHUMP00000031117; OTTHUMP00000031118; OTTHUMP00000031119; OTTHUMP00000031120; OTTHUMP00000016062; SCF apoptosis response protein 1; casein kinase-1 binding protein; chromosome 20 open reading frame 35; dysbindin (dystrobrevin binding protein 1) domain containing 2; dysbindin.
Gene ID : 84062
mRNA Refseq : NM_032122.3
Protein Refseq : NP_115498.2
MIM : 607145
UniProt ID : Q96EV8
Chromosome Location : 6p22.3
Function : identical protein binding.

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