Recombinant Human glycerol-3-phosphate dehydrogenase 2, His-tagged GPD2-106H

Recombinant Human glycerol-3-phosphate dehydrogenase 2, His-tagged

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Recombinant Human glycerol-3-phosphate dehydrogenase 2, His-tagged

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Cat. No. : GPD2-106H
Product Overview : Recombinant Human mGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mGPD protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
Description : Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+-sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus.
Source : E.coli.
Purity : >95% by SDS-PAGE
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [ Homo sapiens ]
Synonyms : GPD2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); GDH2; GPDM; mGPDH; glycerol-3-phosphate dehydrogenase 2, mitochondrial; EC 1.1.5.3; GDH2; GPD-M; GPDH-M; GPDM; mGPDH; mtGPD; mitochondrial glycerophosphate dehydrogenase.
Gene ID : 2820
mRNA Refseq : NM_000408
Protein Refseq : NP_000399
MIM : 138430
UniProt ID : P43304
Chromosome Location : 2q24.1
Pathway : Glycerophospholipid metabolism
Function : calcium ion binding; glycerol-3-phosphate dehydrogenase activity; oxidoreductase activity

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