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Recombinant Human glycerol-3-phosphate dehydrogenase 2, His-tagged

Cat.No. : GPD2-106H
Product Overview : Recombinant Human mGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mGPD protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
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Cat. No. : GPD2-106H
Description : Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+-sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus.
Source : E.coli.
Purity : >95% by SDS-PAGE
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [ Homo sapiens ]
Synonyms : GPD2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); GDH2; GPDM; mGPDH; glycerol-3-phosphate dehydrogenase 2, mitochondrial; EC 1.1.5.3; GDH2; GPD-M; GPDH-M; GPDM; mGPDH; mtGPD; mitochondrial glycerophosphate dehydrogenase.
Gene ID : 2820
mRNA Refseq : NM_000408
Protein Refseq : NP_000399
MIM : 138430
UniProt ID : P43304
Chromosome Location : 2q24.1
Pathway : Glycerophospholipid metabolism
Function : calcium ion binding; glycerol-3-phosphate dehydrogenase activity; oxidoreductase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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