Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 1, His-tagged

• Cat.No.: LAIR1-348H
• Product Overview: Recombinantextracellular domain of LAIR-1( 22-125aa) was overexpressed in E.coli, and purified by using conventional chromatography techniques (105 aa, 11.7 kDa).

Specification

• Cat. No.: LAIR1-348H
• Description: LAIR-1 is a glycoprotein(~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells , B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Lair-1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region.
• Source: E.coli.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 50 mM NaCl, 1 mM EDTA.
• Molecular Weight: 11.7 kDa (105 aa).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequence: MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPS ESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: LAIR1
• Synonyms: LAIR1; leukocyte-associated immunoglobulin-like receptor 1; CD305; LAIR-1; hLAIR1; CD305 antigen; leukocyte-associated Ig-like receptor 1; LAIR1 leukocyte-associated immunoglobulin-like receptor 1.
• Gene ID: 3903
• mRNA Refseq: NM_002287.3
• Protein Refseq: NP_002278.1
• MIM: 602992
• UniProt ID: Q6GTX8
• Chromosome Location: 19q13.4
• Pathway: SNARE interactions in vesicular transport; Membrane Trafficking.
• Function: protein binding; receptor activity.