Recombinant Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1A, His-tagged

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Recombinant Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1A, His-tagged

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Cat. No. : PPP1R1A-341H
Product Overview : Recombinant human IPP-1, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (179 aa, 20 kDa).
Description : Protein phosphatase inhibitor-1(IPP-1) plays an important role in the regulation of glycogen metabolism through inhibition of type-1 protein serine/threonine phosphatase(PP1) activity, and it has been implicated in the regulation of cell growth. IPP-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. In the presence of calcium, PPI-1 is inactivated by calcineurin (or PP2B).
Source : E.coli.
Formulation : Liquid. In 50 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 1 mM EDTA, 0.1 mM PMSF, 10% glycerol.
Molecular Weight : 20 kDa (179 aa).
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequence : MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS VLEHHHHHH
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PPP1R1A
Synonyms : PPP1R1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A; I-1; IPP-1; IPP1; inhibitor-1; protein phosphatase inhibitor-1; Protein phosphatase inhibitor 1.
Gene ID : 5502
mRNA Refseq : NM_006741.3
Protein Refseq : NP_006732.3
UniProt ID : Q13522
Chromosome Location : 15q15.1-q15.2
Pathway : Long-term potentiation.
Function : protein binding; protein serine/threonine phosphatase inhibitor activity.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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