Recombinant Human Proteasome Subunit, Beta Type-1, His-tagged

• Cat.No.: PSMB1-128H
• Product Overview: Recombinant human PSMB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography,27.7 kDa (250aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PSMB1 (Proteasome subunit, beta type-1) encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. The main function of PSMB1 is to degrade unnecessary or damaged proteins by proteolysis.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFS PYVFNGGTIL AIAGEDFAIV ASDTRLSEGF SIHTRDSPKC YKLTDKTVIG CSGFHGDCLT LTKIIEARLK MYKHSNNKAM TTGAIAAMLS TILYSRRFFP YYVYNIIGGL DEEGKGAVYS FDPVGSYQRD SFKAGGSASA MLQPLLDNQV GFKNMQNVEH VPLSLDRAMR LVKDVFISAA ERDVYTGDAL RICIVTKEGI REETVSLRKD
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 10% glycerol
• Purity: > 95% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 [ Homo sapiens ]
• Synonyms: EC 3.4.25.1; FLJ25321; HC5; KIAA1838; PMSB1; PSC5; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain; proteasome (prosome, macropain) subunit, beta type, 1; proteasome beta 1 subunit; proteasome subunit HC5; PSMB1;Proteasome subunit beta type-1
• Gene ID: 5689
• mRNA Refseq: NM_002793
• Protein Refseq: NP_002784
• MIM: 602017
• UniProt ID: P20618
• Chromosome Location: 6q27
• Pathway: Proteasome; Apoptosis; Cell Cycle Checkpoints; Cell Cycle, Mitotic; DNA Replication; HIV Infection; Metabolism of amino acids; Signaling by Wnt
• Function: peptidase activity; protein binding; threonine-type endopeptidase activity