"RCAN1" Related Products

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Recombinant Human Regulator of Calcineurin 1

Cat. No.: RCAN1-298H
Product Overview: Recombinant HumanRCAN1 protein produced in E.Coli encodes 117 (1-117) amino acids and has a molecular mass of 13 kDa.The protein is purified by using conventional chromatography techniques.
Description: The Down"s syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down"s syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a.
Source: E.coli.
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 100 mM NaCl.
Molecular Weight: 13 kDa (117aa).
Purity: > 90% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequence: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: RCAN1
Synonyms: RCAN1; regulator of calcineurin 1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78; RCAN1; Adapt78; calcipressin 1; near DSCR proline-rich protein; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; calcium and oxidant-inducible mRNA; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1.
Gene ID: 1827
mRNA Refseq: NM_004414.5
Protein Refseq: NP_004405.3
MIM: 602917
UniProt ID: P53805
Chromosome Location: 21q22.1-q22.2; 21q22.12
Function: protein binding; transcription factor activity.

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