Recombinant Human Regulator of Calcineurin 1

• Cat.No.: RCAN1-298H
• Product Overview: Recombinant HumanRCAN1 protein produced in E.Coli encodes 117 (1-117) amino acids and has a molecular mass of 13 kDa.The protein is purified by using conventional chromatography techniques.

Specification

• Cat. No.: RCAN1-298H
• Description: The Down"s syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down"s syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a.
• Source: E.coli.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 100 mM NaCl.
• Molecular Weight: 13 kDa (117aa).
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequence: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: RCAN1
• Synonyms: RCAN1; regulator of calcineurin 1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78; RCAN1; Adapt78; calcipressin 1; near DSCR proline-rich protein; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; calcium and oxidant-inducible mRNA; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1.
• Gene ID: 1827
• mRNA Refseq: NM_004414.5
• Protein Refseq: NP_004405.3
• MIM: 602917
• UniProt ID: P53805
• Chromosome Location: 21q22.1-q22.2; 21q22.12
• Function: protein binding; transcription factor activity.