||Recombinant HumanRCAN1 protein produced in E.Coli encodes 117 (1-117) amino acids and has a molecular mass of 13 kDa.The protein is purified by using conventional chromatography techniques.
||The Down"s syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down"s syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a.
||Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 100 mM NaCl.
||13 kDa (117aa).
||> 90% by SDS – PAGE.
||1 mg/ml (determined by Bradford assay).
||MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
||Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.