Recombinant Human TRAIL-R1, Fc Chimera

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Recombinant Human TRAIL-R1, Fc Chimera

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Cat.No. : TNFRSF10A-49H
Product Overview : Produced in HEK 293 cells. The extracellular domain of human TRAIL-R1 (aa 1 - 238) is fused to the Fc portion of human IgG1.
Description : DR4 is a transmembrane protein, also called TRAIL receptor 1 (TRAIL-R1). The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Source : HEK293 cells
Species : Human
Tag : Fc
Notes : Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
SDS-PAGE Electrophoresis of Recombinant Human TRAIL-R1, Fc Chimera .Lane 1 to 3: Recombinant Human TRAIL-R1, Fc Chimera . Staining with Coomassie Blue. :

Gene Name : TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
Official Symbol : TNFRSF10A
Synonyms : TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; APO2; TRAILR1; TRAILR-1; MGC9365;
Gene ID : 8797
mRNA Refseq : NM_003844
Protein Refseq : NP_003835
MIM : 603611
UniProt ID : O00220
Chromosome Location : 8p21
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem;
Function : TRAIL binding; death receptor activity; protein binding; receptor activity; transcription factor binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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