Recombinant Human Apo Transferrin (ATF)

• Cat.No.: TF-62H

Specification

• Description: Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture.It is referred to frequently as a growth factor because, in analogy to other growth factor-receptor interactions, proliferating cells express high numbers of transferrin receptors, and the binding of transferrin to their receptors is needed for cells to initiate and maintain their DNA synthesis. Apart from its role as an iron transport protein transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capacity.Protein Applications:Human Transferrin is a crucial component for the cultivation and long-term cells growth of mammalian cells in-vitro. It is often used as a nutrient in fermentation media for recombinant protein and biopharmaceutical production.Additional common uses of Human Transferrin are:Molecular weight, Affinity purification of anti-human transferrin antibodies.Receptor mediated transfection of molecules such as DNA, into cells.
• Species: Human
• Molecular Mass: Human Apo Transferrin is a glycoprotein of approximately 77 kDa.
• Purity: Greater than 98.0% as determined by Cellulose Acetate Electrophoresis.
• Storage: Lyophilized Apo Transferrin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Apo Transferrin should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
• Reconstitution: It is recommended to reconstitute the lyophilized Apo Transferrin in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.

Gene Information

• Gene Name: TF transferrin [ Homo sapiens ]
• Official Symbol: TF
• Synonyms: TF; transferrin; serotransferrin; PRO1557; PRO2086; siderophilin; beta-1 metal-binding globulin; TFQTL1; DKFZp781D0156
• Gene ID: 7018
• mRNA Refseq: NM_001063
• Protein Refseq: NP_001054
• MIM: 190000
• UniProt ID: P02787
• Chromosome Location: 3q21
• Pathway: EPHB forward signaling, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Hemostasis, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem
• Function: ferric iron binding; metal ion binding; protein binding; ubiquitin protein ligase binding