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Active Recombinant Mouse IGFBP3, carrier free

Cat.No. : Igfbp3-7M
Product Overview : Recombinant Mouse IGFBP3, expressed in Murine myeloma cell line.
  • Specification
  • Gene Information
  • Related Products
Description : The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF.
Source : Mammalian cells
Species : Mouse
Predicted N Terminal : N-Terminal= Pro22
Form : Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Bio-activity : Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast aden centigradearcinoma cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.
Molecular Mass : 40-50 kDa, reducing conditions
Endotoxin : <1.0 eu per 1 μg of the protein by the lal</1.0
Purity : >95%, by SDSPAGE under reducing conditions and visualized by silver stain.
Usage : FOR RESEARCH USE ONLY
Quality Control Test : 12 months from date of receipt, 20 to 70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, 20 to 70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Warning : Avoid repeated freeze-thaw cycles.
Gene Name : Igfbp3 insulin-like growth factor binding protein 3 [ Mus musculus ]
Official Symbol : Igfbp3
Synonyms : IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3; IGgfbp3; AI649005;
Gene ID : 16009
mRNA Refseq : NM_008343
Protein Refseq : NP_032369
UniProt ID : P47878
Chromosome Location : 11 A1; 11 4.75 cM
Pathway : Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; PluriNetWork, organism-specific biosystem; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function : fibronectin binding; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor binding; protein tyrosine phosphatase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic factors that influence IGFBP3 protein levels? 08/11/2022

Yes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.

How does IGFBP3 protein influence bone health? 11/24/2021

IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.

Are there any side effects associated with therapies targeting IGFBP3? 08/04/2021

The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.

How do lifestyle factors such as diet and exercise influence IGFBP3 levels? 04/23/2021

Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.

What are the implications of IGFBP3 deficiency in children's growth and development? 01/14/2021

IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.

Customer Reviews (3)

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Reviews
05/04/2020

    A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.

    01/20/2019

      A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.

      01/02/2019

        This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.

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