Active Recombinant Mouse IGFBP3, carrier free
Cat.No. : | Igfbp3-7M |
Product Overview : | Recombinant Mouse IGFBP3, expressed in Murine myeloma cell line. |
- Specification
- Gene Information
- Related Products
Description : | The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. |
Source : | Mammalian cells |
Species : | Mouse |
Predicted N Terminal : | N-Terminal= Pro22 |
Form : | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
Bio-activity : | Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast aden centigradearcinoma cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. |
Molecular Mass : | 40-50 kDa, reducing conditions |
Endotoxin : | <1.0 eu per 1 μg of the protein by the lal</1.0 |
Purity : | >95%, by SDSPAGE under reducing conditions and visualized by silver stain. |
Usage : | FOR RESEARCH USE ONLY |
Quality Control Test : | 12 months from date of receipt, 20 to 70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, 20 to 70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Warning : | Avoid repeated freeze-thaw cycles. |
Gene Name : | Igfbp3 insulin-like growth factor binding protein 3 [ Mus musculus ] |
Official Symbol : | Igfbp3 |
Synonyms : | IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3; IGgfbp3; AI649005; |
Gene ID : | 16009 |
mRNA Refseq : | NM_008343 |
Protein Refseq : | NP_032369 |
UniProt ID : | P47878 |
Chromosome Location : | 11 A1; 11 4.75 cM |
Pathway : | Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; PluriNetWork, organism-specific biosystem; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem; |
Function : | fibronectin binding; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor binding; protein tyrosine phosphatase activator activity; |
Products Types
◆ Recombinant Protein | ||
IGFBP3-110I | Active Recombinant Human IGFBP3 Protein (264 aa) | +Inquiry |
IGFBP3-2678H | Recombinant Human IGFBP3 protein(121-200 aa), C-His-tagged | +Inquiry |
Igfbp3-10570M | Recombinant Mouse Igfbp3 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGFBP3-2039R | Recombinant Rhesus Macaque IGFBP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGFBP3-4353H | Recombinant Human IGFBP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IGFBP3-1230CCL | Recombinant Cynomolgus IGFBP3 cell lysate | +Inquiry |
IGFBP3-2927HCL | Recombinant Human IGFBP3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.
IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.
The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.
Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.
IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.
Customer Reviews (3)
Write a reviewA manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.
A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.
This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.
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