Native Human TGF- β1

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Native Human TGF- β1

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Cat.No. : TGFB1-21H
Product Overview : Purified from human platelets. Human blood products should always be treated in accordance with universal handling precautions.
Description : Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that centigradecur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains ass centigradeiated with the latent portion of the molecule.
Source : human platelets
Species : Human
Form : Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% TFA, containing 50 μg of bovine serum albumin per 1 μg of cytokine.
Bio-activity : Measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells. Resazurin dye was used in the assay as a fluorescence indicator for cell proliferation (Tsang, M. et al., 1995, Cytokine 7:389). The ED50 for this effect is typically 0.04 - 0.1 ng/mL.
Molecular Mass : The mature disulfide-linked homodimeric human TGF-β1 contains two 112 amino acid residue peptides and has a predicted molecular mass of approximately 25 kDa.
Endotoxin : < 1.0 eu per 1 μg of the cytokine as determined by the lal
Purity : >97%, as determined by SDS-PAGE and visualized by silver stain.
Usage : FOR RESEARCH USE ONLY
Quality Control Test : Lyophilized samples are stable for up to twelve months from date of receipt at -20 centigrade to -70 centigrade. Upon reconstitution, this cytokine can be stored under sterile conditions at 2° - 8 centigrade for one month or at -20 centigrade to -70 centigrade in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile 4 mM HCl containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a st centigradek solution of no less than 1 μg/mL.
Warning : Avoid repeated freeze-thaw cycles.
Gene Name : TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
Official Symbol : TGFB1
Synonyms : TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB;
Gene ID : 7040
mRNA Refseq : NM_000660
Protein Refseq : NP_000651
MIM : 190180
UniProt ID : P01137
Chromosome Location : 19q13.1
Pathway : ACE Inhibitor Pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function : enzyme binding; eukaryotic cell surface binding; growth factor activity; protein N-terminus binding; protein binding; protein heterodimerization activity; protein homodimerization activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding;

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