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Recombinant Mouse Pgk1, His-tagged

Cat.No. : Pgk1-52M
Product Overview : Recombinant mouse Pgk1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Description : Pgk1 also known as Phosphoglycerate kinase 1 is an X-linked enzyme that plays a key role in the glycolytic pathway. Pgk1 acts as a polymerase alpha cofactor protein (primer recognition protein) as a glyxolytic enzyme role. This protein catalyzes the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate during glycolysis, generating one molecule of ATP.
Source : E.coli
Species : Mouse
Tag : His
Form : Liquid, In Phosphate buffered saline (pH7.4) containing 10% glycerol, 1mM DTT
Molecular Mass : 47.1kDa (441aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMSLSNK LTLDKLDVKG KRVVMRVDFN VPMKNNQITN NQRIKAAVPS IKFCLDNGAK SVVLMSHLGR PDGVPMPDKY SLEPVAAELK SLLGKDVLFL KDCVGPEVEN ACANPAAGTV ILLENLRFHV EEEGKGKDAS GNKVKAEPAK IDAFRASLSK LGDVYVNDAF GTAHRAHSSM VGVNLPQKAG GFLMKKELNY FAKALESPER PFLAILGGAK VADKIQLINN MLDKVNEMII GGGMAFTFLK VLNNMEIGTS LYDEEGAKIV KDLMSKAEKN GVKITLPVDF VTADKFDENA KTGQATVASG IPAGWMGLDC GTESSKKYAE AVGRAKQIVW NGPVGVFEWE AFARGTKSLM DEVVKATSRG CITIIGGGDT ATCCAKWNTE DKVSHVSTGG GASLELLEGK VLPGVDALSN V
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Bradford assay)
Gene Name : Pgk1 phosphoglycerate kinase 1 [ Mus musculus ]
Official Symbol : Pgk1
Synonyms : PGK1; phosphoglycerate kinase 1; Pgk-1; MGC118097;
Gene ID : 18655
mRNA Refseq : NM_008828
Protein Refseq : NP_032854
Pathway : Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate =>fructose-6P, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem; Glucose metabolism, organism-specific biosystem; Glycolysis, organism-specific biosystem;
Function : ADP binding; ATP binding; kinase activity; nucleotide binding; phosphoglycerate kinase activity; phosphoglycerate kinase activity; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is PGK1 linked to neurological disorders? 06/27/2019

PGK1 dysfunction has been associated with neurological conditions like Alzheimer's disease and Parkinson's disease due to its impact on cellular energy metabolism.

In what way does PGK1 affect cancer? 11/29/2018

PGK1 is often upregulated in cancer cells, aiding their rapid growth and proliferation by enhancing glycolysis, known as the Warburg effect.

Can PGK1 be a target for cancer treatment? 09/17/2018

Research suggests that targeting PGK1 could potentially be a strategy for cancer therapy by disrupting the energy production in cancer cells.

Are there any PGK1 inhibitors or activators in development for clinical use? 01/11/2018

Several compounds that modulate PGK1 activity are being studied, but none have reached widespread clinical use yet.

Are there diagnostic uses for PGK1 in cancer? 01/17/2016

Yes, elevated levels of PGK1 have been identified in certain cancers, making it a potential biomarker for cancer detection and prognosis.

Customer Reviews (3)

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03/14/2020

    manufacturers may offer customization options, allowing researchers to tailor the PGK1 protein to their specific needs.

    02/27/2020

      This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.

      04/15/2016

        They can also address any questions or concerns regarding the PGK1 protein, thereby facilitating smooth and efficient research execution.

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