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Recombinant Human CTSB protein, His-tagged

Cat.No. : CTSB-169H
Product Overview : Recombinant Human CTSB(Arg18-Ile339 (pro) & Phe74-Ile339 (mature)) fused with His tag at C-terminal was expressed in NS0.
Description : Cathepsin B is the first described member of the family of lysosomal cysteine proteases. Cathepsin B possesses both endopeptidase and exopeptidase activities, in the latter case acting as a peptidyl-dipeptidase. It is known to process a number of proteins, including pro and active caspases, prorenin and secretory leucoprotease inhibitor (SLPI). Therefore, Cathepsin B may play a role in activation and inactivation of caspases, activation of renin and inactivation of SLPI, the key steps in apoptosis, angiotensin production, and progression of emphysema, respectively. Because of its increased levels and redistribution of the enzyme in human and animal tumors, Cathepsin B may also have role in invasion and metastasis.In addition to lysosome, Cathepsin B can be secreted or associated with plasma membrane, cytoplasm, and nucleus. It is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme.
Source : NS0
Species : Human
Tag : His
Predicted N Terminal : Arg18 & Phe74
Form : Supplied as a 0.2 μm filtered solution in Tris and NaCl.
Bio-activity : Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC. The specific activity is >2,500 pmol/min/µg, as measured under the described conditions.
Molecular Mass : Predicted Molecular Mass: 37 (Pro) & 29 (Mature) kDa;SDS-PAGE: 43 kDa and 36 kDa, reducing conditions.
Protein length : Arg18-Ile339 (pro) & Phe74-Ile339 (mature)
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 centigrade as supplied.3 months, -20 to -70 centigrade under sterile conditions after opening.
Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : CTSB cathepsin B [ Homo sapiens ]
Official Symbol : CTSB
Synonyms : CTSB; cathepsin B; cathepsin B1; APP secretase; cysteine protease; amyloid precursor protein secretase; APPS; CPSB;
Gene ID : 1508
mRNA Refseq : NM_001908
Protein Refseq : NP_001899
MIM : 116810
UniProt ID : P07858
Chromosome Location : 8p23.1
Pathway : Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Toll Receptor Cascades, organism-specific biosystem;
Function : cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding;

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