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Recombinant Human AMOTL2 lysate

Cat.No. : AMOTL2-19HCL
Product Overview : Over-expression cells lysed in RIPA buffer and lysate supplied in SDS loading buffer
  • Specification
  • Gene Information
  • Related Products
Source : HEK 293 cells
Species : Human
Molecular Mass : 55168.06Da
Recommended Usage : WB
Storage Instruction : Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Gene Name : AMOTL2 angiomotin like 2 [ Homo sapiens ]
Official Symbol : AMOTL2
Synonyms : LCCP
Gene ID : 51421
mRNA Refseq : NM_016201.2
Protein Refseq : NP_057285.3
MIM : 614658
UniProt ID : Q9Y2J4
Chromosome Location : 3q21-q22
Pathway : Signal Transduction, organism-specific biosystem;Signaling by Hippo, organism-specific biosystem;
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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Are there any known drugs or therapies that target AMOTL2? 12/07/2022

Currently, there are no known drugs or therapies specifically targeting AMOTL2. As research on AMOTL2 is still ongoing and its functions and interactions are being elucidated, therapeutic interventions targeting this protein have not yet been developed. However, as our understanding of the role of AMOTL2 in various diseases expands, it may become a target of interest for drug development in the future.

How is AMOTL2 involved in cancer? 07/01/2022

The role of AMOTL2 in cancer is complex and can be context-dependent. Alterations in the expression of AMOTL2 have been observed in various types of cancer, suggesting its potential involvement in tumorigenesis. In some cases, reduced expression of AMOTL2 has been associated with cancer progression and poor prognosis. For example, decreased AMOTL2 expression has been reported in breast cancer, hepatocellular carcinoma, and lung adenocarcinoma. This reduced expression is thought to contribute to tumor growth, invasion, and metastasis.

Can AMOTL2 be used as a diagnostic marker for any diseases? 04/08/2022

AMOTL2 has been investigated as a potential diagnostic marker for certain diseases, particularly in the context of cancer. The altered expression of AMOTL2 in specific cancer types, as mentioned earlier, suggests its potential as a diagnostic marker. In some studies, decreased expression of AMOTL2 has been implicated as a prognostic indicator in breast cancer, hepatocellular carcinoma, and lung adenocarcinoma.

Does AMOTL2 have any known functions in development? 06/28/2021

Yes, AMOTL2 has been implicated in development processes. It is involved in embryonic blood vessel development and angiogenesis, similar to AMOTL1. AMOTL2 has also been shown to play a role in heart development, where it regulates cardiac morphogenesis and chamber formation. These roles highlight the importance of AMOTL2 in embryonic and organ development.

Are there any genetic disorders associated with AMOTL2 mutations? 05/06/2021

There is limited information available regarding genetic disorders specifically associated with AMOTL2 mutations. However, variations in the AMOTL2 gene have been identified in genetic studies related to disorders like autism spectrum disorder and schizophrenia. These variations may potentially impact the function or expression of AMOTL2, but further research is needed to determine the exact implications of AMOTL2 mutations in these disorders.

Does AMOTL2 have any known roles in the nervous system? 01/22/2021

Yes, AMOTL2 has been implicated in various processes within the nervous system. It is involved in neural tube closure during early embryonic development, where it regulates cell adhesion and migration of neural cells. AMOTL2 has also been shown to play a role in the development of dendritic spines, which are important for neuronal communication. Additionally, AMOTL2 expression has been detected in the brain, suggesting its potential role in neuronal function and homeostasis.

Can AMOTL2 be targeted for therapeutic purposes? 12/29/2020

Although there is currently no specific therapeutic targeting of AMOTL2, its involvement in various cellular processes and its altered expression in certain diseases suggest its potential as a target for therapeutic interventions. Further research is needed to fully understand the molecular mechanisms and biological functions of AMOTL2, which could provide insights into its therapeutic potential.

What are the cellular processes regulated by AMOTL2? 06/18/2020

AMOTL2 is involved in various cellular processes. It plays a role in endothelial cell migration and tube formation during angiogenesis, where it interacts with proteins like VE-cadherin and RhoA to regulate cytoskeletal rearrangements. AMOTL2 also influences cell polarity and cell adhesion by modulating tight junction integrity. In addition, it participates in the regulation of cell proliferation and cell cycle progression through its interactions with the Hippo and Wnt signaling pathways.

Is AMOTL2 expressed in all tissues or is its expression specific to certain organs? 05/04/2020

The expression of AMOTL2 is not ubiquitous and is known to be tissue-specific in certain contexts. Its expression has been detected in various tissues and organs, including the heart, lung, kidney, liver, and brain. In some tissues, such as the vascular endothelium, AMOTL2 expression is relatively high due to its role in angiogenesis. However, the exact expression pattern of AMOTL2 in different tissues and its regulation in specific cell types require further investigation.

In what tissues or organs is AMOTL2 expressed? 06/08/2019

AMOTL2 is expressed in various tissues and organs. It is widely found in endothelial cells lining blood vessels, which is consistent with its role in angiogenesis. AMOTL2 expression has also been observed in the heart, brain, lung, liver, kidney, and other tissues. The specific expression patterns may vary depending on the developmental stage and physiological context.

Is AMOTL2 involved in cell signaling pathways? 10/29/2018

Yes, AMOTL2 participates in several signaling pathways. It interacts with YAP and TAZ, key components of the Hippo signaling pathway, and influences their localization and activity. AMOTL2 also interacts with β-catenin and DVL2, which are involved in the Wnt/β-catenin signaling pathway. These interactions suggest that AMOTL2 can modulate the activity of these pathways, affecting gene expression and cellular processes.

How does AMOTL2 interact with other proteins? 10/16/2018

AMOTL2 can interact with several other proteins, similar to AMOTL1. It interacts with YAP and TAZ, transcriptional co-activators that regulate gene expression in the Hippo signaling pathway. AMOTL2 also associates with components of the Wnt/β-catenin pathway, like β-catenin and DVL2. Additionally, AMOTL2 can interact with other members of the angiomotin family, such as AMOT and AMOTL1, forming protein complexes that influence cellular processes.

Can AMOTL2 regulate cell migration and invasion? 07/26/2018

Yes, AMOTL2 has been associated with cell migration and invasion in various contexts. It regulates endothelial cell migration and tube formation during angiogenesis, implicating its role in blood vessel development. In cancer cells, altered expression of AMOTL2 has been linked to increased cell migration and invasion, suggesting its involvement in tumor metastasis. The exact mechanisms through which AMOTL2 influences these processes are still under investigation.

Is AMOTL2 associated with any diseases or disorders? 10/12/2017

AMOTL2 has been implicated in certain diseases and disorders. In cancer, altered expression of AMOTL2 has been reported in various types of tumors, suggesting its involvement in tumor development and progression. AMOTL2 has been associated with increased cell migration and invasion in cancer cells. However, further research is needed to fully understand the role of AMOTL2 in cancer and other diseases.

Are there any known diseases or disorders associated with AMOTL2? 10/26/2016

There are currently no specific diseases or disorders that are directly linked to mutations or dysregulation of AMOTL2. However, alterations in the expression of AMOTL2 have been observed in certain cancers. For example, decreased expression of AMOTL2 has been reported in breast cancer and hepatocellular carcinoma, and increased expression has been associated with poor prognosis in glioblastoma. Further studies are needed to fully understand the role of AMOTL2 in these diseases and determine its potential as a therapeutic target.

Are there any known interactions or associations between AMOTL2 and other proteins? 10/10/2016

Yes, AMOTL2 interacts with various proteins to regulate cellular processes.

Customer Reviews (5)

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Reviews
11/19/2021

    In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

    10/17/2021

      The AMOTL2 protein comes highly recommended for its outstanding performance in various experimental applications.

      06/13/2019

        I have successfully implemented the AMOTL2 protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

        08/24/2018

          Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the AMOTL2 protein in various research studies.

          01/30/2018

            when utilized in Western Blotting experiments, the AMOTL2 protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

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