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Recombinant Human F9 therapeutic protein

Cat.No. : F9-P026H
Product Overview : Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX.
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  • Gene Information
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Description : This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. The expression product is the active ingredient of Benefix.
Species : Human
Molecular Mass : 46.55 kDa
Protein length : 415 Aa
AA Sequence : YNSGKLEEFVQGNLERECMEEKCSF EEAREVFENTERTTEFWKQYVDGDQ CESNPCLNGGSCKDDINSYEC WCPFGFEGKNCELDVTCNIKNGRCE QFCKNSADNKVVCSCTEGYRLAENQ KSCEPAVPFPCGRVSVSQTSK LTRAEAVFPDVDYVNSTEAETILDN ITQSTQSFNDFTRVVGGEDAKPGQF PWQVVLNGKVDAFCGGSIVNE KWIVTAAHCVETGVKITVVAGEHNI EETEHTEQKRNVIRIIPHHNYNAAI NKYNHDIALLELDEPLVLNSY VTPICIADKEYTNIFLKFGSGYVSG WGRVFHKGRSALVLQYLRVPLVDRA TCLRSTKFTIYNNMFCAGFHE GGRDSCQGDSGGPHVTEVEGTSFLT GIISWGEECAMKGKYGIYTKVSRYV NWIKEKTKLT
Endotoxin : < 1.0 EU per μg of the protein
Purity : >95%
Storage : Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.
Gene Name : F9 coagulation factor IX [ Homo sapiens ]
Official Symbol : F9
Synonyms : F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component; F9 p22; FIX F9; factor 9; factor IX F9; serine protease; Christmas factor; plasma thromboplastin component; P19; PTC; HEMB; THPH8; MGC129641; MGC129642;
Gene ID : 2158
mRNA Refseq : NM_000133
Protein Refseq : NP_000124
MIM : 300746
UniProt ID : P00740
Chromosome Location : Xq26.3-q27.1
Pathway : Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Extrinsic Pathway, organism-specific biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem;
Function : calcium ion binding; peptidase activity; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the function of F9 protein? 12/18/2019

The F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.

How do genetic mutations in the F9 protein affect its function? 12/04/2019

Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.

Do F9 protein mutations cause other diseases or affect other physiological processes? 05/27/2019

F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.

What diseases can F9 gene mutations cause? 05/22/2019

Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.

How is the activity of F9 protein determined? 04/08/2019

The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).

What is the structure of F9 protein? 01/31/2019

F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.

Customer Reviews (3)

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Reviews
04/15/2021

    The short half-life makes this product very safe.

    10/10/2020

      This protein has a wide range of applications and can be used in a variety of experiments.

      03/27/2019

        The method of use is simple, which reduces the experimental time and improves the efficiency.

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