"SP3" Related Products


Recombinant Human SP3, MYC/DDK-tagged

Cat.No.: SP3-104H
Product Overview: Recombinant Human SP3, fused to C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
Source: HEK293 cells
Species: Human
Molecular Mass: 81.7 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: SP3 Sp3 transcription factor [ Homo sapiens (human) ]
Official Symbol: SP3
Synonyms: Sp3 transcription factor; SP3; SPR2; DKFZp686O1631; SPR-2; specificity protein 3; GC-binding transcription factor Sp3; DKFZp686O1631
Gene ID: 6670
mRNA Refseq: NM_003111
Protein Refseq: NP_003102
MIM: 601804
UniProt ID: Q02447
Chromosome Location: 2q31
Pathway: Regulation of Telomerase; SIDS Susceptibility Pathways; Selenium Metabolism and Selenoproteins
Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; chromatin binding

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