Recombinant Human CSF2 CSF2-22H

Recombinant Human CSF2

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Recombinant Human CSF2

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Cat.No. : CSF2-22H
Product Overview : Recombinant Human GM-CSF is a 14 to 36 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two N-linked glycosylation sites.
Description : The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
Source : CHO Cells
Species : Human
Form : 0.22 um filtered solution in 20 mM TRIS*HCl buffer pH 7.2
Bio-activity : ED50<1 ng/ml, The activity was determined by the dose dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line)
Molecular Mass : 14-36 kDA, glycosylated
AA Sequence : APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKG PLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, Determined by SDS-PAGE under reducing conditions and visualized by silver stain.
Gene Name : CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens (human) ]
Official Symbol : CSF2
Synonyms : CSF2; colony stimulating factor 2 (granulocyte-macrophage); GMCSF; MGC131935; MGC138897; colony stimulating factor 2; molgramostin; sargramostim; granulocyte-macrophage colony stimulating factor; GM-CSF; Molgramostin; Sargramostim; Colony-stimulating factor
Gene ID : 1437
mRNA Refseq : NM_000758
Protein Refseq : NP_000749
MIM : 138960
UniProt ID : P04141
Chromosome Location : 5q31.1
Pathway : Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Cytokine Signaling in Immune system; Cytokines and Inflammatory Response
Function : cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity

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