"HAMP" Related Products


Recombinant Human HAMP, MYC/DDK-tagged

Cat.No.: HAMP-12H
Product Overview: Recombinant Human HAMP, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
Source: HEK293 cells
Species: Human
Molecular Mass: 6.9 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: HAMP hepcidin antimicrobial peptide [ Homo sapiens (human) ]
Official Symbol: HAMP
Synonyms: HAMP; hepcidin antimicrobial peptide; HEPC; PLTR; HFE2B; LEAP1; hepcidin; liver-expressed antimicrobial peptide 1; putative liver tumor regressor
Gene ID: 57817
mRNA Refseq: NM_021175
Protein Refseq: NP_066998
UniProt ID: P81172
Chromosome Location: 19q13.1
Pathway: Iron metabolism in placenta
Function: hormone activity

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