"TIGIT" Related Products

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Recombinant Human TIGIT, Fc-tagged

Cat.No.: TIGIT-107H
Product Overview: Recombinant Human TIGIT(Met 22 - Pro 141), fused with a human IgG1 Fc tag at the C-terminus, was expressed in human 293 cells.
Description: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Source: HEK293
Species: Human
Tag: Fc
Predicted N Terminal: Met 22
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: rh TIGIT / VSIG9 / VSTM3 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 39.7 kDa. The predicted N-terminus is Met 22. DTT-reduced Protein migrates as 40-55 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh TIGIT / VSIG9 / VSTM3 Fc Chimera by the LAL method.
Purity: >92% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name: TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens (human) ]
Official Symbol: TIGIT
Synonyms: TIGIT; VSIG9; VSTM3; WUCAM; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
Gene ID: 201633
mRNA Refseq: NM_173799
Protein Refseq: NP_776160
MIM: 612859
UniProt ID: Q495A1
Chromosome Location: 3q13.31
Pathway: Cell adhesion molecules (CAMs)
Function: protein binding; receptor binding

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