"FGFR2" Related Products

Recombinant Human FGFR2, MYC/DDK-tagged

Cat.No.: FGFR2-82H
Product Overview: Recombinant Human FGFR2, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Molecular Mass: 89.7 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens (human) ]
Official Symbol: FGFR2
Synonyms: FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; BEK fibroblast growth factor receptor; FGF receptor; FGFR2-AHCYL1 fusion kinase protein; bacteria-expressed kinase; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; protein tyrosine kinase, receptor like 14; protein tyrosine kinase, receptor like 14; NP_000132.3; EC 2.7.10.1; NP_001138385.1; NP_001138386.1; NP_001138387.1; NP_001138387.1; NP_001138388.1; NP_001138390.1; NP_001138391.1; NP_075259.4; NP_075418.1
Gene ID: 2263
mRNA Refseq: NM_000141
Protein Refseq: NP_000132
MIM: 176943
UniProt ID: P21802
Chromosome Location: 10q26
Pathway: Activated point mutants of FGFR2; Central carbon metabolism in cancer; Downstream signal transduction
Function: fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; heparin binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.