Recombinant Human CES2


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Recombinant Human CES2

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Cat.No. : CES2-1140H
Product Overview : Recombinant Human CES2 was expressed in Baculovirus-Insect cells.
Source : baculovirus infected BTI insect cells
Species : Human
Bio-activity : Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.Carboxylesterase 2 human identifies the site containing a large alcohol and small acyl group. It shows less transesterification activity due to presence of conformational interference in active site.
Molecular Mass : It has two glycosylation sites at 103 and 267 residues with molecular mass 60kDa.
Applications : Carboxylesterase 2 may play a key role in biotransformation of a variety of ester containing drugs and prodrugs.
Storage : −70ºC
Shipping : dry ice
Gene Name : CES2 carboxylesterase 2 [ Homo sapiens (human) ]
Official Symbol : CES2
Synonyms : CES2; carboxylesterase 2; iCE; CE-2; PCE-2; CES2A1; cocaine esterase; carboxylesterase 2 (intestine, liver); hCE-2; intestinal carboxylesterase; liver carboxylesterase-2; methylumbelliferyl-acetate deacetylase 2; NP_003860.2; EC; EC; EC; NP_932327.1
Gene ID : 8824
mRNA Refseq : NM_003869
Protein Refseq : NP_003860
MIM : 605278
UniProt ID : O00748
Chromosome Location : 16q22.1
Pathway : Drug metabolism - other enzymes; E2F transcription factor network; Fluoropyrimidine Activity; Phase I, non P450
Function : carboxylic ester hydrolase activity; methylumbelliferyl-acetate deacetylase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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