Recombinant Human CR1 therapeutic protein

• Cat.No.: CR1-P016H
• Product Overview: Recombinant Human complement receptor 1 therapeutic protein is a complement inhibitor currently under development for treatment of rheumatoid arthritis and I/RI. It consists of the first three short consensus domains of human complement receptor 1, manufactured in recombinant bacteria and modified with a membrane-targeting amphiphilic peptide based on the naturally occurring membrane-bound myristoyl-electrostatic switch peptide.

Specification

• Description: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
• Species: Human
• Endotoxin: < 1.0 EU per μg of the protein
• Purity: >98%

Gene Information

• Gene Name: CR1 complement component (3b/4b) receptor 1 (Knops blood group) [ Homo sapiens ]
• Official Symbol: CR1
• Synonyms: CR1; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1, including Knops blood group system; complement receptor type 1; CD35; KN; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component receptor 1; C3BR; C4BR
• Gene ID: 1378
• mRNA Refseq: NM_000573
• Protein Refseq: NP_000564
• MIM: 120620
• UniProt ID: P17927
• Chromosome Location: 1q32
• Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem
• Function: complement component C3b binding; complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; receptor activity