Native Human alpha-1 proteinase inhibitor therapeutic protein (Aralast, Aralast NP, Glassia, Prolastin, Prolastin-C, Zemaira)

• Cat.No.: SERPINA1-P035H
• Product Overview: Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by?PEG and zinc chloride fractionation.

Specification

• Description: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
• Source: human plasma
• Species: Human
• CAS number: 9041-92-3
• Molecular Mass: 44.32 kDa
• AA Sequence: EDPQGDAAQKTDTSHHDQDHPTFNK ITPNLAEFAFSLYRQLAHQSNSTNI FFSPVSIATAFAMLSLGTKAD THDEILEGLNFNLTEIPEAQIHEGF QELLRTLNQPDSQLQLTTGNGLFLS EGLKLVDKFLEDVKKLYHSEA FTVNFGDTEEAKKQINDYVEKGTQG KIVDLVKELDRDTVFALVNYIFFKG KWERPFEVKDTEEEDFHVDQV TTVKVPMMKRLGMFNIQHCKKLSSW VLLMKYLGNATAIFFLPDEGKLQHL ENELTHDIITKFLENEDRRSA SLHLPKLSITGTYDLKSVLGQLGIT KVFSNGADLSGVTEEAPLKLSKAVH KAVLTIDEKGTEAAGAMFLEA IPMSIPPEVKFNKPFVFLMIEQNTK SPLFMGKVVNPTQK
• Endotoxin: < 0.1 eu per μg of the
• Purity: >96%

Gene Information

• Gene Name: SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [ Homo sapiens ]
• Official Symbol: SERPINA1
• Synonyms: SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; PI, serine (or cysteine) proteinase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 1; alpha-1-antitrypsin; A1A; A1AT; AAT; alpha 1 antitrypsin; alpha1AT; PI1; protease inhibitor 1 (anti elastase); serpin A1; alpha-1-antiproteinase; alpha-1-antitrypsin null; alpha-1 protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1; PI; PRO2275; MGC9222; MGC23330
• Gene ID: 5265
• mRNA Refseq: NM_000295
• Protein Refseq: NP_000286
• MIM: 107400
• UniProt ID: P01009
• Chromosome Location: 14q32.1
• Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; FOXA1 transcription factor network, organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem
• Function: protease binding; protein binding; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity