Recombinant Human ARSB therapeutic protein
| Cat.No. : |
ARSB-P038H |
| Product Overview : |
Recombinant Human N-acetylgalactosamine 4-sulfatase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant?DNA origin. It is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family. |
- Specification
- Gene Information
- Related Products
| Description : |
It is a lysosomal hydrolase that catalyzes the cleavage of the sulfate ester from terminal N-acetylgalactosamine 4-sulfate residues of GAG chondroitin 4-sulfate and dermatan sulfate. Increased catabolism of GAG in turn reduces systemic dermatan sulfate accumulation, thereby reducing the primary symptoms of MPS VI. |
| Species : |
Human |
| Molecular Mass : |
56 kDa |
| Protein length : |
495 aa |
| AA Sequence : |
SGAGASRPPHLVFLLADDLGWNDVG FHGSRIRTPHLDALAAGGVLLDNYY TQPLCTPSRSQLLTGRYQIRT GLQHQIIWPCQPSCVPLDEKLLPQL LKEAGYTTHMVGKWHLGMYRKECLP TRRGFDTYFGYLLGSEDYYSH ERCTLIDALNVTRCALDFRDGEEVA TGYKNMYSTNIFTKRAIALITNHPP EKPLFLYLALQSVHEPLQVPE EYLKPYDFIQDKNRHHYAGMVSLMD EAVGNVTAALKSSGLWNNTVFIFST DNGGQTLAGGNNWPLRGRKWS LWEGGVRGVGFVASPLLKQKGVKNR ELIHISDWLPTLVKLARGHTNGTKP LDGFDVWKTISEGSPSPRIEL LHNIDPNFVDSSPCPRNSMAPAKDD SSLPEYSAFNTSVHAAIRHGNWKLL TGYPGCGYWFPPPSQYN VSEIPSSDPPTKTLWLFDIDRDPEE RHDLSREYPHIVTKLLSRLQFYHKH SVPVYFPAQDPRCDPKATGVW GPWM |
| Endotoxin : |
< 0.1 EU per μg of the protein |
| Purity : |
>95% |
| Gene Name : |
ARSB arylsulfatase B [ Homo sapiens ] |
| Official Symbol : |
ARSB |
| Synonyms : |
ASB; G4S; MPS6; arylsulfatase B |
| Gene ID : |
411 |
| mRNA Refseq : |
NM_000046 |
| Protein Refseq : |
NP_000037 |
| MIM : |
611542 |
| UniProt ID : |
P15848 |
| Chromosome Location : |
5q14.1 |
| Pathway : |
CS/DS degradation, organism-specific biosystem; Chondroitin sulfate degradation, conserved biosystem; Glycosaminoglycan degradation, organism-specific biosystem |
| Function : |
N-acetylgalactosamine-4-sulfatase activity; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity |
Products Types
Related Gene
ARSB
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
